TY - JOUR AU - Haidari, Murtaza AU - Alami, Kawsar AU - Hossaini, Arefa AU - Mousavi, Sayed Yousof PY - 2020/12/30 Y2 - 2024/03/29 TI - Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats JF - International Journal of Ayurvedic Medicine JA - IJAM VL - 11 IS - 4 SE - Research Articles DO - 10.47552/ijam.v11i4.1691 UR - https://www.ijam.co.in/index.php/ijam/article/view/1691 SP - 759-764 AB - <p>Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan <em>Hibiscus sabdariffa L.</em> and <em>Carum Carvi L.</em> hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of <em>H. sabdariffa</em> (75, 150 and 300 mg/kg), <em>C. carvi</em> (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21<sup>st </sup>days. The results showed a significant (P&lt;0.0001) hypoglycemic effect of <em>H. sabdariffa</em> extract (75, 150 and 300 mg/kg) on 7, 14 and 21<sup>th </sup>days, <em>C. carvi</em> extract (500 mg/kg), and their effective doses combination (75:25), especially on 7<sup>th</sup> day. Only 75 mg/kg of <em>H. sabdariffa</em> had positive effect on body weight loss of diabetic rats (P&lt;0.05). One can conclude that Afghan <em>H. sabdariffa</em> and <em>C. carvi</em> hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of <em>H. sabdariffa</em> was much greater and even normalized the blood glucose level.</p> ER -