TY - JOUR AU - Arjunan, Archana AU - Sah, Dhiraj Kumar AU - Rajan, Ravindran PY - 2021/06/17 Y2 - 2024/03/28 TI - Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats JF - International Journal of Ayurvedic Medicine JA - IJAM VL - 12 IS - 2 SE - Research Articles DO - 10.47552/ijam.v12i3.1871 UR - https://www.ijam.co.in/index.php/ijam/article/view/1871 SP - 226-231 AB - <p>Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of <em>Glycyrrhiza glabra </em>(GG) on stress-induced male Wistar albino rats.&nbsp;&nbsp;Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days),&nbsp;&nbsp;Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p&lt;0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.</p> ER -