Triphala improves glucose homeostasis by alleviating atherogenic lipids and oxidative stress in human Type 2 diabetes mellitus

  • Nita Singh SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
  • Sunil Mahajan SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
  • Senthil K Subramani SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
  • Dhananjay Yadav Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • Lokendra Singh Director, Defence research and development establishment, Gwalior, Madhya Pradesh-474001, India
  • Prasad GBKS SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
Keywords: Type 2 diabetes, impaired glucose tolerance, Lipid metabolism, Glucose metabolism, Oxidative stress, Antioxidants, Ayurvedic formulations

Abstract

Aims: ‘Triphala’ constituting equal parts of three medicinal dried plant fruits Emblica Officinalis Gaertn., Terminalia chebula Retz. and Terminalia bellerica Gaertn. is an antioxidant rich Ayurvedic formulation. The present study assessed therapeutic as well as protective effects of Triphala on human subjects with Type 2 diabetes mellitus (T2DM) and Impaired glucose tolerance (IGT). 

Materials and methods: Triphala at a dose of 5 gms BD was administered to two cohorts viz., IGT, N= 20 and T2DM, N=30 consecutively for a period of 12 months. The therapeutic efficacy was assessed quarterly by monitoring blood glucose and lipid levels; the protective effect by monitoring antioxidants level quarterly and DNA damage annually. Toxicity if any, to liver and kidney due to long term administration was assessed quarterly in both cohorts.

Results: Continuous ‘Triphala’ therapy for 12 months significantly reduced blood glucose (p≤0.001) and lipid levels (p≤0.05) in both the cohorts. Triphala resisted oxidative stress generated during the course of hyperglycemia by significantly increasing the activity of super oxide dismutase and Catalase (p≤0.001) and the level of reduced glutathione (p≤0.001). Protective effect on DNA was accessed through significant reduction in the comet tail length (p≤0.001).

Conclusions: ‘Triphala’ ameliorated not only the oxidative stress but also normalized glucose and lipid homeostasis in subjects with impaired glucose and T2DM.

 

Author Biographies

Nita Singh, SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011, PhD
Sunil Mahajan, SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011, MSc.
Senthil K Subramani, SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011, MSc
Dhananjay Yadav, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, PhD.

Lokendra Singh, Director, Defence research and development establishment, Gwalior, Madhya Pradesh-474001, India
Defence research and development establishment, Gwalior, Madhya Pradesh-474001, India, Director
Prasad GBKS, SOS in Biochemistry, Jiwaji University, Gwalior, Madhya Pradesh-474011
Prof. GBKS Prasad, Ph.D
Dean'    Faculty of Life Sciences
Jiwaji University
Gwalior, India - 474 011 
Published
2015-09-25
Section
Research Articles