Blood glucose lowering efficacy of Avartaki Churna in Streptozotocin-induced Hyperglycemia in rats
Objective: To evaluate the hypoglycemic effect of Avartaki Churna (Cassia auriculata Linn.) in experimental animals. Materials and Methods: Avartaki Churna was prepared by the standard procedure of Churna Kalpana. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intra-peritoneal [i.p.]) 35 mg/kg.Â After assessment of hyperglycemia as an approximate induction of diabetes, Group IV animals were treated with 300 mg/kg of Avartaki Churna. For treatment comparison, Group III animals were treated with a standard hypoglycemic drug, glibenclamide 1 mg/kg. Blood sugar level was assessed by glucometer on the 7th, 14th, 21stÂ and 28thÂ Â day. Results: Avartaki Churna produced a significantly reduction of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, Avartaki Churna produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: Avartaki Churna and glibenclamide significantly reduced blood sugar level. The results were more significant with successive days in this in vivo comparative study.
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