Blood glucose lowering efficacy of Avartaki Churna in Streptozotocin-induced Hyperglycemia in rats

  • Guruprasad C Nille Banaras Hindu University
  • Reddy K R C Banaras Hindu University
  • Anshuman Trigunayat
Keywords: Avartaki Churna, Prameha, Streptozotocin

Abstract

Objective: To evaluate the hypoglycemic effect of Avartaki Churna (Cassia auriculata Linn.) in experimental animals. Materials and Methods: Avartaki Churna was prepared by the standard procedure of Churna Kalpana. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intra-peritoneal [i.p.]) 35 mg/kg.  After assessment of hyperglycemia as an approximate induction of diabetes, Group IV animals were treated with 300 mg/kg of Avartaki Churna. For treatment comparison, Group III animals were treated with a standard hypoglycemic drug, glibenclamide 1 mg/kg. Blood sugar level was assessed by glucometer on the 7th, 14th, 21st  and 28th   day. Results: Avartaki Churna produced a significantly reduction of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, Avartaki Churna produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: Avartaki Churna and glibenclamide significantly reduced blood sugar level. The results were more significant with successive days in this in vivo comparative study.

 

Author Biography

Anshuman Trigunayat
Department of Pharmacology, Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Published
2016-06-25
Section
Research Articles