Anti Hyperglycemic, Anti Oxidant, Anti Hyperlipidemic & Nephroprotective Effect of Stevioside in Diabetic Rats

  • Ambily Scaria St.Johns college of pharmaceutical sciences and research, Kattappana,Kerala,India-685515
  • Jagadhish V Kamath Principal and HOD, Shree Devi College of Pharmacy, Mangalore 574142, India
  • Manodeep Chakraborty Department of Pharmacology, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India
Keywords: Stevioside, Alloxan, nephropathy, antioxidants, histopathology

Abstract

Objective: The present study aimed to evaluate in vivo the antihyperglycemic, anti oxidant,antihyperlipidemic and nephroprotective effects of Stevioside against Alloxan induced diabetic nephropathy in rats. Materials and Methods: In this model diabetes was induced using Alloxan (125 mg/kg, i.p) and the prophylactic treatment was started 48 hours after Alloxan injection for 28 days. The protective effect of the treatment with standard (Glibenclamide 0.5mg/kg, p.o) and Stevioside (250 mg/kg. p.o) were analyzed by estimating the serum levels of glucose, urea, creatinine, albumin, total protein, total cholesterol (TCH), triglycerides (TG), high density lipoproteins (HDL) and antioxidants like SOD, catalase and lipid peroxidation. Key Findings: This study demonstrates that Stevioside improved hyperglycemia and maintained antioxidant status and reduced total cholesterol, TG, urea, creatinine and albumin and lipid peroxidation levels when compared to toxic control. The protective effect of Stevioside against Alloxan induced diabetic nephropathy in rats was also supported by histopathologic findings.The results of the present study are encouraging for its potential use to delay the onset and progression of diabetic renal complications. However, the translation of therapeutic efficacy in humans requires further studies.

Author Biographies

Ambily Scaria, St.Johns college of pharmaceutical sciences and research, Kattappana,Kerala,India-685515
Lecturer,Pharmacology
Jagadhish V Kamath, Principal and HOD, Shree Devi College of Pharmacy, Mangalore 574142, India
Principal & HOD,Pharmacology
Manodeep Chakraborty, Department of Pharmacology, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India
Associate professor,Pharmacology
Published
2017-12-26
Section
Research Articles