Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats

Keywords: Afghanistan, Hibiscus sabdariffa, Carum carvi, Combination, Blood glucose level

Abstract

Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.

Author Biographies

Murtaza Haidari

Research and Technology Center, Khatam Al-Nabieen University, Kabul, Afghanistan.

Kawsar Alami

Research and Technology Center, Khatam Al-Nabieen University, Kabul, Afghanistan.

Arefa Hossaini

Research and Technology Center, Khatam Al-Nabieen University, Kabul, Afghanistan.

Sayed Yousof Mousavi

Assistant professor, Department of physiology, Khatam Al-Nabieen University, Kabul, Afghanistan.

Published
2020-12-30
How to Cite
Haidari, M., Alami, K., Hossaini, A., & Mousavi, S. Y. (2020). Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats. International Journal of Ayurvedic Medicine, 11(4), 759-764. https://doi.org/10.47552/ijam.v11i4.1691
Section
Research Articles