Comparative study on efficacy of two Ayurvedic formulations by stress induced gastric ulcers and hypothermia
Keywords:Narikela Khanda, Narikela Khanda granules, Gastric ulcer, Swimming stress, Anti-ulcer activity
Gastric disorders like hyperacidity and ulcers are a common clinical entity. A rational therapy for gastric ulcers still remains elusive and search for safer potential drugs is being carried out. The present comparative experimental study was planned to see the efficacy of two Ayurvedic formulations i.e. Narikela Khanda (Cocus nucifera candy) and Narikela Khanda granules by using swimming stress induced ulcers and hypothermia in albino rats. Wister strain albino rats of either sex were divided into three groups, each group consists of six animals. Here group 'A' received Narikela Khanda suspension, while group 'B' received Narikela Khanda granules suspension and group 'C' received dose of tap water which served as stress control group. Narikela Khanda and Narikela Khanda granules were prepared in house laboratory of the department. Wister strain albino rats of either sex weighing between 150-250g were selected for the study. Effects of both the formulations were assessed on different parameters like change in body weight, effect on rectal temperature and ulcer index. Body weight decrease was seen in both the formulations compared to initial body weight. Both the formulations did not affect the rectal temperature to significant extent in comparison to stress control group. An apparent and statistically highly significant decrease in ulcer index was observed in both the test formulations treated group in comparison to stress control group. The magnitude of anti-ulcer effect was found to be higher in Narikela Khanda granules treated group.
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