Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats

  • Archana Arjunan
  • Dhiraj Kumar Sah
  • Ravindran Rajan
Keywords: Anxiety, Fear, Glycyrrhiza glabra, Hippocampus, Lateral ventricle, Noise, Obsessive-compulsive, Stress

Abstract

Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats.  Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days),  Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p<0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.

Author Biographies

Archana Arjunan

Research Scholar, Department of Physiology, Dr. Arcot Lakshmanaswamy Mudhaliar Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai.

Dhiraj Kumar Sah

Research Scholar, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.

Ravindran Rajan

Associate Professor & Head, Department of Physiology, Dr. Arcot Lakshmanaswamy Mudhaliar Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai.

Published
2021-06-17
How to Cite
Arjunan, A., Sah, D., & Rajan, R. (2021). Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats. International Journal of Ayurvedic Medicine, 12(2), 226-231. https://doi.org/10.47552/ijam.v12i3.1871
Section
Research Articles