A Pilot study to assess the safety of Rasamanikya (An Arsenical formulation) in healthy volunteers

  • Nilima N Wadnerwar
  • Abhay H Patkar
Keywords: Heavy metal toxicity, Rasamanikya, Safety, Preclinical study

Abstract

Backround: Ayurvedic medicines are alleged to be one of the sources of heavy metal toxicity. Hence, it has become necessary to prove their safety on the scientific base with appropriate evidences. Methodology: A pilot study was conducted after the preclinical safety evaluation of Rasamanikya, an arsenical formulation in Ayurveda. Ten healthy volunteers were administered Rasamanikya 125mg twice a day for fifteen consecutive days. Heavy metal estimation in blood was conducted before intervention and at the end of intervention. Student’s paired t test was applied at 5% level of significance. Result: Out of nine heavy metals, only Arsenic in blood was increased significantly in all the ten volunteers without any signs of clinical toxicity. Conclusion: The drug was found to be safe as evidenced in the previous preclinical study.

Author Biographies

Nilima N Wadnerwar

Associate Professor, Department of Agadtantra, Mahatma Gandhi Ayurved College, Hospital & Research Centre, Salod (H), Datta Meghe Institute of Medical Sciences (DU), Wardha, Maharashtra.

Abhay H Patkar

Professor, Department of Agadtantra, A.S.S. Ayurved Mahavidyalaya, M.U.H.S. Nashik; Adjacent Faculty, Department of Agadtantra, Mahatma Gandhi Ayurved College, Hospital & Research Centre, Salod (Hirapur), Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha-442001, Maharashtra. 

Published
2021-06-29
How to Cite
Wadnerwar, N., & Patkar, A. (2021). A Pilot study to assess the safety of Rasamanikya (An Arsenical formulation) in healthy volunteers. International Journal of Ayurvedic Medicine, 12(2), 286-288. https://doi.org/10.47552/ijam.v12i3.1877
Section
Research Articles