Thrombolytic effect of Siddha herbal formulation Sikkanjar Manapagu using in-Silico model

Authors

  • Panneerselvam N R
  • Anbarasan B
  • Subathra T

DOI:

https://doi.org/10.47552/ijam.v12i4.2252

Keywords:

Docking study, Thrombolytic, Siddha formulation, Sikkanjar manapagu, Human Plasminogen Activation Loop Peptide - PDB 4DCB

Abstract

Background: Thromboembolic disorders are one of the important causes leading to death. In the Siddha system of medicine, many drugs have been mentioned in the literature and their thrombolytic potential needs to be scientifically evaluated. Aim: The study aims to perform the In Silico computational studies of Phytoconstituents of Siddha formulation Sikkanjar Manapagu (SM) to evaluate its thrombolytic potential. Methods: Autodock program was used for the molecular docking studies of the retrieved phytoconstituents such as Zingiberene, Gingerenone-A, 6 Gingerol of Zingiber officinale, Menthol, Luteolin, Citronellol of Mentha arvensis, Eugenol, Limonene, Myrcene, and Linalool of Citrus aurantium against target protein Human Plasminogen Activation Loop Peptide - PDB 4DCB. Results: A total of ten compounds were screened, of these Zingiberene, Menthol, Citronellol, Eugenol, Limonene, Myrcene, and Linalool showed high binding against active amino acid residue 195. Conclusion: Based on further experiments and clinical trials, the formulation Sikkanjar Manapagu could be proved to be effective in thrombolytic treatment.

Author Biographies

Panneerselvam N R

Professor, Department of Kuzhanthai Maruthuvam, Sri Sai Ram Siddha Medical College and Research Centre, Sai Leo Nagar,  Tambaram West, Chennai. India. 

Anbarasan B

Assistant Professor, Department of Maruthuvam, National Institute of Siddha, Tambaram Sanatorium, Chennai,  India.

Subathra T

Ph.D. Scholar, Department of Nanju Maruthuvam, National Institute of Siddha, Tambaram Sanatorium, Chennai, India.

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Published

31-12-2021

How to Cite

N R, P., B, A., & T, S. (2021). Thrombolytic effect of Siddha herbal formulation Sikkanjar Manapagu using in-Silico model. International Journal of Ayurvedic Medicine, 12(4), 908–911. https://doi.org/10.47552/ijam.v12i4.2252

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Section

Research Articles