Aqueous extract of Daucus carota exerts a protective effect on the Renal, Hepatic and Duodenal mucosal histology in Diclofenac Induced Tissue Injury

Authors

DOI:

https://doi.org/10.47552/ijam.v14i1.3327

Keywords:

Daucus carota, Diclofenac, Duodenum, Ethnobotany, Glomerulus, Hepatotoxicity

Abstract

Objective: The use of ethnobiology in treatment of many diseases especially in rural residents with limited access to medical technology, treatment and equipment is beneficial and necessary. Daucus carota (DC) root extract was used as pre-treatment in adult Wistar rats exposed to diclofenac sodium (DF) to investigate a protective effect on the histology of liver, kidney and duodenum. Materials and Method: Twenty-five adult Wistar rats were used for this study and were randomly divided into 5 groups of 5 rats each, which included: Group A - Normal control; Group B – 50mg/kg DF control; Group C – 50mg/kg DC + 50mg/kg DF, Group D – 100mg/kg DC + 50mg/kg DF; and, Group E – 140mg/kg DC + 50mg/kg DC. Results and Discussion: The results showed a reduction in damage to the hepatocytes, maintenance of sinusoidal integrity and reduction in the number of inflammatory cells in the hepatic parenchyma, In the kidney tissue, the extract preserved the glomerular capillary tuft, renal tubular epithelial cells, conserved Bowman’s space and lining epithelium of the capsule in a dose dependent manner. The intestinal mucosa in groups treated with higher doses of the extract were completely preserved and intact with minimal erosion of  epithelial lining along with preservation of lamina propria and intestinal glands. Conclusion: Pre-administration of DC, preferably at concentrations of 100mg/kg and 140mg/kg reduced hepatotoxicity, renal tissue and mucosal layer damage in the duodenum following administration of DF. This preservation of tissues improved as concentration of the extract increased verifying that its efficiency was dose dependent. 

Author Biographies

Iliyasu Zanna

Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Borno State, Nigeria. 

Yunus Ibrahim

Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Borno State, Nigeria.

Ibrahim Nasir

Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Borno State, Nigeria. 

Martha Orendu Oche Attah

Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Borno State, Nigeria. Faculty of Medicine, Cyprus International University, Nicosia, Cyprus.

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Published

04-04-2023

How to Cite

Zanna, I. ., Ibrahim, Y., Nasir, I., & Attah, M. O. O. (2023). Aqueous extract of Daucus carota exerts a protective effect on the Renal, Hepatic and Duodenal mucosal histology in Diclofenac Induced Tissue Injury. International Journal of Ayurvedic Medicine, 14(1), 99–104. https://doi.org/10.47552/ijam.v14i1.3327

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Section

Research Articles