Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice

Abstract

Obesity is directly associate to cancer, diabetes, cardiovascular diseases and hypertension  producing severe complication of  health and economic costs  in  a global scale. This study aims to validate the anti-obesity potential of the peel of Opuntia joconostle hydroethanolic extract  (XOCO) on obesity in high-fat diet (HFD)-induced obese C57BL/6 mice. Therefore, the phenolic compounds and flavonoids  profiles were investigated by colorimetric assay. We are using a HFD  induced obesity in mice and after orally administered 200, 300 and  mg/kg XOC for 5 weeks. At the end of the experimental period was determined body weight, food intake, serum biochemical parameters,  fat weight, organ and a histological analysis.  This research demonstrated that the peel of the investigated  xoconostle had a significantly amount of flavonoids, showing  highest level of total phenolic compound  (58.15 mg GAE/g  of extract) and flavonoid content (59.12 mg CE/g of extract). XOC Treatment in HFD-fed mice decreases adipogenesis, total body fat, the absolute body weight, lipidemia, glucose levels,  leptin, and resistin, and increases HDL-CHO levels and adiponectin. In histological analysis showed  inhibition of the deposition of fat droplets in the liver. Findings indicated  that XOC  has anti-obesity effects in obesity-induced mice. This potential anti-obesity effect  may be due to phenolic compounds content in the extract.