A Clinical Study to Evaluate the Antihypertensive Effect of Herbal Formulation (Cap Punarnavadi Mishran) in Management of Primary Hypertension

Abstract

The present clinical study aimed to evaluate the antihypertensive efficacy of a polyherbal formulation, Capsule Punarnavadi Mishran, in the therapeutic management of primary hypertension. A total  number of 30 patients diagnosed with primary hypertension were enrolled from both outpatient and inpatient departments of Dr. D. Y. Patil Ayurved College and Hospital, Pimpri, Pune (Maharashtra). All participants received Capsule Punarnavadi Mishran as a part of their treatment regimen over a defined study period. The effectiveness of the intervention was assessed using both objective parameters primarily changes in systolic and diastolic blood pressure and subjective clinical symptoms. Blood pressure measurements were recorded at baseline and at regular intervals during the course of treatment. The results demonstrated a statistically significant reduction in both systolic and diastolic blood pressure among all 30 participants. Based on clinical assessment, 6 patients (20%) exhibited excellent improvement, 14 patients (46.7%) showed moderate improvement, while 10 patients (33.3%) demonstrated mild to moderate symptomatic relief. The formulation was well-tolerated, and no adverse events were reported during the trial. These findings suggest that Capsule Punarnavadi Mishran may offer a promising adjunct or alternative in the management of primary hypertension. Further large-scale, randomized controlled studies are recommended to validate these preliminary results and elucidate the underlying pharmacological mechanisms.