Antibacterial and Antifungal activity of Arseno-Mercurial formulation Sameerapannaga Rasa: An in-vitro study
DOI:
https://doi.org/10.47552/ijam.v16i2.5715Keywords:
Herbomineral Drug, Antimicrobial activity, Sameerapannaga Rasa, Rasa-aushadhi, Vata-pannaga RasaAbstract
Background: Sameerpannaga Rasa (SPR) is a herbomineral formulation categorized as a Kupipakwa Rasayana, one of the four types of Rasayanas in Rasashastra.
Materials & Methods: After proper shodhan of the individual ingredients, the SPR was prepared by the kupipakwa method and the anti-microbial activity was assessed through standard and internationally accepted methods like MIC (Minimum inhibitory concentration) & MBC (Minimum bactericidal concentration) methods.
Results and Discussion: The minimum inhibitory concentration of Sameerapannaga rasa showed very good inhibitory activity against all the tested organisms. SPR demonstrated strong antimicrobial activity against S. aureus, K. pneumoniae, C. albicans, S. sanguis, and S. pneumoniae at low concentrations (0.9 mg). Sameerapannaga rasa exhibited antimicrobial effects against S. epidermidis (31.25 mg), P. aeruginosa (125 mg), P. mirabilis (62.5 mg), E. coli, and C. krusei (7.8 mg).
Minimum bactericidal concentration of Sameerapannaga rasa showed very significant inhibitory activity against all the tested organisms. SPR demonstrated strong antibacterial and antifungal activity against E. coli, S. pneumoniae, and C. albicans at low concentrations (0.9 mg). It also showed activity against S. aureus (15.6 mg), K. pneumoniae (1.96 mg), S. sanguis (7.8 mg), C. krusei (62.5 mg), P. aeruginosa and P. mirabilis (125 mg), and S. epidermidis (250 mg).
Conclusion: The results of both Minimum inhibitory concentration and Minimum bactericidal concentration methods provided scientific evidence of the potential antimicrobial activity of SPR, therefore Sameerapannaga rasa could be considered as a potential alternative to the contemporary treatment.
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