A Gastro Retentive Drug Delivery System of Perindopril using Natural Polymer – Development and Optimization

Abstract

Gastro retentive floating matrix tablet provides drug delivery at the controlled rate, improve bioavailability and prolong the retention of dosage forms in gastrointestinal tract. Okra gum, a mucilage-rich extract derived from the okra plant (Abelmoschus esculentus), holds significant value in both Ayurvedic medicine and modern pharmaceutical sciences. Knowing the importance of Okra gum, aim of present investigation is to develop gastro retentive floating matrix tablet of Perindopril using Avicel pH 102 as a directly compressible material; Citric acid for production of acidic microenvironment and sodium-bi-Carbonate as gas generating agent. Pre-compression parameters of powdered blend as well as prepared batches were studied and found within the range. FTIR of physical mixture (Perindopril, Okra gum and HPMCK4M) suggesting no incompatibility. Formulation batch F8floated, and remained buoyant without disintegration with swelling index value 42.32%, releasedPerindopril 92.92% about 12 hours might be due to combine use of HPMC K4M & Okra gum; showed higher correlation coefficient (r²-value) followed Korsmeyer Peppas release kinetics. DSC thermogram of F8 confirms uniform dispersion of drug in an amorphous form as endothermic peak was below 126.0⁰. No significant changes in physiochemical properties, drug release profile as well as drug content of optimized F8 batch when subjected to stability at 40± 2⁰temperature with relative humidity 75±5% for three monthsindicating there was no degradation and change in the matrix system.