Formulation And Evaluation of Herbal Emulgel for Treatment of Psoriasis

Abstract

One of the most prevalent skin conditions in humans, psoriasis is thought to have strong genetic roots. It is characterized by abnormal keratinocyte differentiation and excessive development, however with the right treatment, it is completely curable. The development of psoriatic plaques is associated with environmental triggers and other factor such as streptococcal infection, physical trauma (such as tattoos and surgical incisions), smoking and alcohol abuse, as well as certain medications such as antidepressant drugs, anti-hypertensive drugs, anti-cytokine medication. The formulation goal is to develop an emulgel infused with a combination of herbs such as Neem oil, Coconut oil and Aloevera gel, that can help to alleviate the symptoms of Psoriasis and also to cure the condition. The prepared gel formulations were evaluated for pH, viscosity, drug content uniformity, physical characterization, phytochemical screening and by also evaluating it’s effect on psoriasis affected skin. Aloevera and neem oil, and coconut oil containing emulgel exhibited the drug content within the optimum range 87.56%-90.45% which concluded efficient drug loading in the formulation.