Integrative management of chronic leg ulcer in Sickle cell disease: A case report on T-AYU-HM Premium and ACUPEN Therapy

Abstract

Background: Sickle cell disease (SCD) is associated with chronic complications, including non-healing leg ulcers. These are difficult to manage due to factors like poor perfusion, hemolysis, oxidative stress, and malnutrition. This case report explores the role of two Ayurvedic formulations, T-AYU-HM Premium and ACUPEN, in treating chronic leg ulcers in an SCD patient. Case Presentation: An 18-year-old male with SCD presented with multiple chronic ulcers on the left ankle and tibia. Associated symptoms included septic discharge, severe anemia (Hb: 6.25 g/dL), elevated CRP (31.16 mg/dL), leukocytosis, and high bilirubin. He had intermittently used T-AYU-HM since 2010. A comprehensive treatment plan including T-AYU-HM Premium, ACUPEN (oral and topical), antibiotics, analgesics, and hematinics was initiated. Outcome: By November 2024, significant improvements were observed: hemoglobin increased to 10.63 g/dL, CRP dropped to 4.8 mg/dL, and the ulcers healed with scar formation. Inflammation reduced significantly, dorsiflexion improved, and both bilirubin and reticulocyte levels stabilized. Discussion: The combination of T-AYU-HM Premium and ACUPEN facilitated hematological recovery and accelerated wound healing. T-AYU-HM supported erythropoiesis, while ACUPEN enhanced microcirculation and reduced edema. Both addressed systemic and local ulcer pathogenesis. Conclusion: Integrating Ayurvedic therapies with conventional treatments may effectively manage SCD-related leg ulcers, but further studies are needed to confirm these findings.