Boswellia serrata Gum-Derived Polysaccharide Beads for Enhanced Antioxidant Stabilization and Protection

Authors

  • Saptarshi Samajdar Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Kolkata- 700125, India.
  • Surya Sekhar Mondal Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Kolkata- 700125, India.
  • Baisnabdas Pathak Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Kolkata- 700125, India.

DOI:

https://doi.org/10.47552/ijam.v17i2.6981

Keywords:

Boswellia serrata, Polysaccharide, Polymeric beads, Antioxidant, Andrographis paniculata, Ionotropic gelation, Natural biomaterial

Abstract

Natural polysaccharides are gaining prominence as sustainable biomaterials for drug delivery and antioxidant protection. Boswellia serrata gum polysaccharide (BSP), a biopolymer known for its antioxidant and bioadhesive properties, was isolated and employed to develop polymeric beads for sustained antioxidant release of Andrographis paniculata (Kalmegh) extract. BSP was extracted using hot-water extraction, ethanol precipitation, and dialysis, yielding 14.3% purified polysaccharide. Polymeric beads were prepared via ionotropic gelation with calcium alginate as the base and varying concentrations of BSP or dextran as co-polymers. The formulations (F1–F6) were evaluated for physicochemical and functional parameters including particle size, swelling index, entrapment efficiency, drug loading, and in vitro antioxidant capacity using DPPH and H₂O₂ assays over ten weeks. BSP-based formulations exhibited smaller particle sizes (0.63–0.70 mm), higher swelling (up to 86.4%), and superior entrapment efficiency (up to 86%) compared with dextran-based beads. Formulation F6 (BSP 20%) showed the highest drug loading (31%) and maintained strong scavenging activity for ten weeks, indicating sustained release and stability. The findings establish BSP as a natural, biocompatible polymeric carrier capable of extending antioxidant efficacy and suggest its potential application in long-acting nutraceutical and therapeutic formulations.

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Published

2026-06-30

How to Cite

Samajdar, S., Mondal, S. S., & Pathak, B. (2026). Boswellia serrata Gum-Derived Polysaccharide Beads for Enhanced Antioxidant Stabilization and Protection. International Journal of Ayurvedic Medicine, 17(2), 520–526. https://doi.org/10.47552/ijam.v17i2.6981

Issue

Vol. 17 No. 2 (2026): April - June 2026

Section

Research Articles

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